Anthony II became active in politics and in 1821, was appointed Constable after his brother John, resigned.

Anthony Plymale II built his log house across the creek, and about one mile up stream from his brother John's house. He married Mary Pauline (Polly) Ferguson on June 10, 1824. She was a sister to John's wife, Rebecca. Here he raised a large family of thirteen children. He is grandfather of at least 92 children.

Mary Pauline (Polly) Ferguson, died May 13, 1882 at the age of 78.

On July 26, 1882, Anthony Plymale II, at the age of 82, married Sarah Harmon Fuller, a young widow woman with two children. Sarah's husband James Fuller had died leaving her with the two small children. Anthony II and his first wife Mary (Polly), had raised Sarah from the time she was a small child, so she brought her children to the only home she had ever known, and at the time of Anthony's wife's death, was taking care of her. On the day of their marriage, Anthony II and Sarah entered into a marriage contract whereby Anthony agreed to, give her a farm of 100 acres and personal property equal to $1,000 and she agreed to forfeit her right to a widow's dowry at his death. It appears that she needed a home, and he needed a housekeeper in his old days, and this was what they thought was the honorable way for the two to solve their problems.

Anthony II never owned slaves, and he did every thing in his power to help runaway slaves from the southern states to get into a free state. He was a member of the underground railroad, which assisted slaves to liberty. He was also a member of company which bought 500 acres of land in Burlington, Ohio for 37 slaves which were freed by their master in Orange County, Virginia. Their master willed them their liberty at his death, and set aside $10,000 for purchasing land in a free state, and to provide for them until they got settled and established. Today more than one-half of the population of Burlington, Ohio is black.

Anthony Plymale II was a Baptist minister and he founded the "Buffalo Valley Baptist Church" in 1850 and preached the first sermon in the building. It was destroyed by a cyclone in May, 1965 but has since been rebuilt.  (Click Here to see a recent photo of this church.)

Anthony Plymale II over a long period of time bought several thousand acres of land. He, like his brother John, sold the timber off his lands, and as his children married, gave them large tracts of land as wedding presents. When his daughter Elizabeth married William Haynie, he gave her 130 acres on Buffalo Creek. When his son Alderson married Adeline Chadwick, he gave them 200 acres on Buffalo Creek. When his daughter Rebecca married 0-1-3-3-1 John “Plymale” Malcolm (cousins), he gave them 175 acres on Buffalo Creek. When his son, William C. L. Plymale married Prudence Ferguson, he gave them a large tract of land on Queens Fork of Hurricane Creek.

In Anthony's will, he gave his old home farm, where he first settled to his son Anthony Wayne Plymale, but reserved one acre of ground where the cemetery now is for a burial ground for his family and their descendants. It is in this cemetery that Anthony II and his first wife Mary (Polly) are buried.